[AF-FORUM] 95S 倍他阻滞诱发心动过缓. Dr. Rondon

[AF Symposium]

Perez Riera医生

感谢你关于随机试验优越性的论述。

现在，任何人在做研究时都喜欢随机试验，但这也产 
生一个问题，就是对于一些个人对一些疾病的经验知 
识没有考虑进去，一些特殊的患者没有针对性地思考。

当随机试验被无关人员分析时，会更可靠，更值得信 
赖，因为它不知道试验的目的，而仅仅区分实验组和 
对照组，进而实现了随机化。

同样，安慰剂可以保证入选患者个体感觉影响相同， 
在对患者和医生心理影响上也是均衡的。这一点是非 
常重要的影响，但有时候会被研究者忽略，甚至跨越 
此雷池，例如在一些非常著名的实验室/公司出经费 
负担的针对药物研发的研究就会这样，甚至有时候结 
果得到扭曲而不被发现，有时候统计的p值或者卡方 
值很小，与均值相比较大的标准差等等。

随机试验在进行中被认识到这一实验是由非常著名的 
试验室/公司支付研究的，或者参与的学者被这些著 
名的实验室/公司邀请参加各式的活动和会议的时 
候，就可能会产生问题…各位，我不想在这引起的家 
的争论，但是存在着科学事实的本身，以及研究者口 
中的事实两种情况。真正的事实是能够持续的显示效 
用并经得起时间考验的。

Dr Mauricio Rondon
Hospital Universitario de Caracas


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Re: [AF-FORUM] 95S Beta-blocking induced bradycardia. Dr. Rondon

Dr. Perez Riera,
I liked your appreciation and detail about randomization and its
advantages in a research work.
Now, whoever is making this research, generally favors randomization,
and here is the problem, since it is very difficult to make an
abstraction of the personal feeling of knowledge on the disease or a
particular patient.
When randomization is manufactured by someone outside the research,
then it is much more reliable and it provides dependability to the
research, since it removes the knowledge about the reasons for the
research, and only assigns an active medication or placebo, thus
realizing the randomization.
Likewise, the presence of placebo guarantees the behavior of the
individual and personal effect of the patient of feeling in a
research work, which on occasions guarantees an effect of
improvement, which is more or less known, and is something equivalent
to the empathy of the patient with the investigator or treating
physician in a Hospital. This is an important effect and on occasions
forgotten by our investigators and that on occasions could be
overcame, in some works paid by very famous laboratories with the
medication as objective, and even so the results are distorted so
that this is not seen, with a significant P or not and/or square chi
with a lower value, greater or less standard deviation from the
average, etc.
The issue of randomization has drawbacks when we are aware of the
laboratory supporting the investigation and when we are very well
known or invited to conferences and events by these laboratories…
Please, I don't want to cause a controversy, but there are scientific
truths and truths created by investigators. The real truths are those
that can stand the effect of time and show its advantages consistently.
Thank you,

Dr Mauricio Rondon
Hospital Universitario de Caracas

--
Dr. Sergio Dubner
President of Scientific Committee

Dr. Edgardo Schapachnik
President of Steering Committee