<HTML><BODY style="word-wrap: break-word; -khtml-nbsp-mode: space; -khtml-line-break: after-white-space; "><DIV><DIV><DIV class="MsoNormal"><FONT class="Apple-style-span" face="Arial">Dr. Victor Moga from Romania asks</FONT></DIV><DIV class="MsoNormal"><FONT class="Apple-style-span" face="Arial"><BR class="khtml-block-placeholder"></FONT></DIV><DIV class="MsoNormal"><FONT class="Apple-style-span" face="Arial">- Since heart failure is a major cause of mortality, morbity and hospitalization, which is the best approach for clinical application of the cardiac resynchronisation therapy?</FONT></DIV></DIV><DIV><DIV class="MsoNormal"><FONT class="Apple-style-span" face="Arial"><BR class="khtml-block-placeholder"></FONT></DIV><DIV class="MsoNormal"><FONT class="Apple-style-span" face="Arial">Dr. Arthur Moss from U.S.A. answers</FONT></DIV><DIV class="MsoNormal"><FONT class="Apple-style-span" face="Arial"> The approved AHA/ACC/ESC criteria for cardiac resynchronization therapy (CRT) are NYHA III or IV, EF<0.30, and QRS>0.12s in ischemic or non-ischemic heart disease. In patients in sinus rhythm, dual chamber biventricular pacing should be used with the AV interval setting in the physiologic range. Optimization of the device programming usually requires concurrent echo/doppler evaluation. Left cephalic or left subclavian vein approach usually provides the easiest access to the coronary veins. In general the LV pacing electrodes should be placed in the lateral coronary vein and not in the anterior vein</FONT></DIV></DIV></DIV><FONT class="Apple-style-span" face="Arial"><BR></FONT><DIV><DIV><FONT class="Apple-style-span" face="Arial">--</FONT></DIV><DIV><FONT class="Apple-style-span" face="Arial">Dr. Sergio Dubner</FONT></DIV><DIV><FONT class="Apple-style-span" face="Arial">President of Scientific Committee</FONT></DIV><DIV><FONT class="Apple-style-span" face="Arial"><BR></FONT></DIV><DIV><FONT class="Apple-style-span" face="Arial">Dr. Edgardo Schapachnik</FONT></DIV><DIV><FONT class="Apple-style-span" face="Arial">President of Steering Committee</FONT></DIV><DIV><FONT class="Apple-style-span" face="Arial"><BR class="khtml-block-placeholder"></FONT></DIV><DIV><FONT class="Apple-style-span" face="Arial"><BR class="khtml-block-placeholder"></FONT></DIV><FONT class="Apple-style-span" face="Arial"><BR class="Apple-interchange-newline"></FONT></DIV><FONT class="Apple-style-span" face="Arial" size="3"><SPAN class="Apple-style-span" style="font-size: 13px;"><BR></SPAN></FONT></BODY></HTML>