<HTML><BODY style="word-wrap: break-word; -khtml-nbsp-mode: space; -khtml-line-break: after-white-space; "><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102">Dr. Serge Boveda from France asks:</FONT></FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 13px/normal Lucida Grande; min-height: 16px; "><FONT class="Apple-style-span" face="Arial" size="3"><SPAN class="Apple-style-span" style="font-size: 12px;"><FONT class="Apple-style-span" color="#080102"><BR></FONT></SPAN></FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102">- </FONT></FONT><SPAN class="Apple-style-span" style="border-collapse: collapse; "><SPAN lang="EN-US" style=""><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102">One ICD for each post-MI patient: dream or nightmare?</FONT></FONT></SPAN></SPAN></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 13px/normal Lucida Grande; min-height: 16px; "><FONT class="Apple-style-span" face="Arial" size="3"><SPAN class="Apple-style-span" style="font-size: 12px;"><FONT class="Apple-style-span" color="#080102"><BR></FONT></SPAN></FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102">Dr. Beatrice Brembrilla Perrot from France answers</FONT></FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102"><BR class="khtml-block-placeholder"></FONT></FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102">- </FONT></FONT><SPAN lang="EN-US" style=""><SPAN class="Apple-style-span" style="border-collapse: collapse; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102">The answer is nightmare</FONT></FONT><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102"><SPAN lang="EN-US" style=""></SPAN></FONT></FONT></SPAN></SPAN></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><SPAN class="Apple-style-span" style="border-collapse: collapse; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102"><BR class="khtml-block-placeholder"></FONT></FONT></SPAN></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><SPAN lang="EN-US" style="; font-family: Lucida Grande; "><SPAN class="Apple-style-span" style="border-collapse: collapse; "><SPAN lang="EN-US" style="; font-family: Lucida Grande; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102">To wait heart transplantation without risk in a patient, I agree </FONT></FONT><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102"><SPAN lang="EN-US" style=""></SPAN></FONT></FONT></SPAN></SPAN></SPAN></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><SPAN class="Apple-style-span" style="border-collapse: collapse; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102"><BR class="khtml-block-placeholder"></FONT></FONT></SPAN></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><SPAN lang="EN-US" style="; font-family: Lucida Grande; "><SPAN class="Apple-style-span" style="border-collapse: collapse; "><SPAN lang="EN-US" style="; font-family: Lucida Grande; "><SPAN lang="EN-US" style="; font-family: Lucida Grande; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102">To delay the death related to heart failure I disagree</FONT></FONT><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102"><SPAN lang="EN-US" style=""></SPAN></FONT></FONT></SPAN></SPAN></SPAN></SPAN></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><SPAN class="Apple-style-span" style="border-collapse: collapse; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102"><BR class="khtml-block-placeholder"></FONT></FONT></SPAN></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><SPAN lang="EN-US" style="; font-family: Lucida Grande; "><SPAN class="Apple-style-span" style="border-collapse: collapse; "><SPAN lang="EN-US" style="; font-family: Lucida Grande; "><SPAN lang="EN-US" style="; font-family: Lucida Grande; "><SPAN lang="EN-US" style="; font-family: Lucida Grande; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102">One other indication : the contraindication to beta blockers !!</FONT></FONT><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102"><SPAN lang="EN-US" style=""></SPAN></FONT></FONT></SPAN></SPAN></SPAN></SPAN></SPAN></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><SPAN class="Apple-style-span" style="border-collapse: collapse; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102"><BR class="khtml-block-placeholder"></FONT></FONT></SPAN></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><SPAN lang="EN-US" style="; font-family: Lucida Grande; "><SPAN class="Apple-style-span" style="border-collapse: collapse; "><SPAN lang="EN-US" style="; font-family: Lucida Grande; "><SPAN lang="EN-US" style="; font-family: Lucida Grande; "><SPAN lang="EN-US" style="; font-family: Lucida Grande; "><SPAN lang="EN-US" style="; font-family: Lucida Grande; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102">We still need to collect non invasive and invasive studies of our patients to decrease the indications of ICD, to need more precisely the coronary status of these patients (unknown in MADIT) and I hope for the development a real curative treatment (ex cells injection…)</FONT></FONT><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102"><SPAN lang="EN-US" style=""></SPAN></FONT></FONT></SPAN></SPAN></SPAN></SPAN></SPAN></SPAN></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><SPAN class="Apple-style-span" style="border-collapse: collapse; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102"><BR class="khtml-block-placeholder"></FONT></FONT></SPAN></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102"><BR class="khtml-block-placeholder"></FONT></FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><SPAN lang="EN-US" style="; font-family: Lucida Grande; "><SPAN class="Apple-style-span" style="border-collapse: collapse; "><SPAN lang="EN-US" style="; font-family: Lucida Grande; "><SPAN lang="EN-US" style="; font-family: Lucida Grande; "><SPAN lang="EN-US" style="; font-family: Lucida Grande; "><SPAN lang="EN-US" style="; font-family: Lucida Grande; "><SPAN lang="EN-US" style="; font-family: Lucida Grande; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102"> </FONT></FONT><SPAN lang="EN-US" style=""><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102">Sincerely yours</FONT></FONT></SPAN></SPAN></SPAN></SPAN></SPAN></SPAN></SPAN></SPAN><TABLE border="1" cellspacing="0" cellpadding="0" width="1584" style="width: 1584pt; border-top-style: none; border-right-style: none; border-bottom-style: none; border-left-style: none; border-width: initial; border-color: initial; "><TBODY><TR><TD width="109" valign="top" style="width:109.25pt;border:solid windowtext .5pt; padding:0cm 5.4pt 0cm 5.4pt"><DIV class="MsoNormal"><SPAN lang="EN-US" style=""><SPAN class="Apple-style-span" style="border-collapse: collapse; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102">B</FONT></FONT></SPAN><SPAN class="Apple-style-span" style="border-collapse: collapse; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102">éatrice</FONT></FONT></SPAN></SPAN><SPAN lang="EN-US" style=""><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102"><O:P></O:P></FONT></FONT></SPAN></DIV></TD></TR></TBODY></TABLE></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 13px/normal Lucida Grande; min-height: 16px; "><FONT class="Apple-style-span" face="Arial" size="3"><SPAN class="Apple-style-span" style="font-size: 12px;"><FONT class="Apple-style-span" color="#080102"><BR></FONT></SPAN></FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102">-- </FONT></FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102">Dr. Sergio Dubner</FONT></FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102">President of Scientific Committee</FONT></FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; font: normal normal normal 13px/normal Lucida Grande; min-height: 16px; "><FONT class="Apple-style-span" face="Arial" size="3"><SPAN class="Apple-style-span" style="font-size: 12px;"><FONT class="Apple-style-span" color="#080102"><BR></FONT></SPAN></FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102">Dr. Edgardo Schapachnik</FONT></FONT></DIV><DIV style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; "><FONT class="Apple-style-span" face="Arial"><FONT class="Apple-style-span" color="#080102">President of Steering Committee</FONT></FONT></DIV><FONT class="Apple-style-span" face="Arial"><BR></FONT></BODY></HTML>