[SCD-FORUM] 44E RE: 无症状性Brugada综合征病人――Ray Jordan 医师

[SCD Symposium]

44E RE: 无症状性Brugada综合征病人――Ray Jordan 医师
尊敬的李医师：
首先，是否已通过基因研究分析排除了可用来解释离 
子通道病变表型多样性或临床表现多样性的等位基因 
嵌和现象（发生在器官形成和胚胎分化阶段）。还有 
需要说明的一点是，一些等位基因更易在第八脑神 
经、左室、右室等部位出现，而其他部位的起搏细胞 
可完全正常。

Richar-Ray/dba Richard Ray Jordan, M.D., SFM
――
Sergio Dubner 博士
科委会主席
Edgardo Schapachnik 博士
组委会主席

  44E RE: Asymptomatic patient with Brugada syndrome. Dr. Ray Jordan
Dr. Li,
Has genetic research analysis ruled out genetic allele chimerism (at the
time of organogenesis and embryological differentiation) to explain the
phenotypic variety of channelopathies or numerous clinical  
manifestations? Another words are some alleles more likely to find or  
gravitate towards the  eighth nerve, RV, vs LV etc., while other  
regions of pacemaker cells remain  entirely normal?
Richar-Ray/dba Richard Ray Jordan, M.D., SFM

--
Dr. Sergio Dubner
President of Scientific Committee

Dr. Edgardo Schapachnik
President of Steering Committee